PROTEÍNAS DE UNIÓN AL ANTÍGENO GITR

• Main Authors: O'NEILL, JASON C, KET, RANDAL R, FOLTZ, IAN, PIASECKI, JULIA, BEERS, COURTNEY
• Format: Patent
• Language: Spanish
• Published: 27.03.2015
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Proteínas de unión a antígeno que activan GITR. Ácidos nucleicos que codifican para las proteínas de unión a antígeno y vectores y células que contienen dichos ácidos nucleicos. Proteínas de unión a antígeno que son de utilidad en métodos terapéuticos en los cuales es útil estimular la señalización por GITR, induciendo o potenciando de esta forma una respuesta inmune en un sujeto. Por consiguiente, las proteínas de unión a antígeno tienen utilidad en una variedad de tratamientos de inmunoterapia, que incluyen el tratamiento de diferentes cánceres e infecciones. Antigen binding proteins that activate GITR are provided. Nucleic acids encoding the antigen binding proteins and vectors and cells containing such nucleic acids are also provided. The antigen binding proteins have value in therapeutic methods in which it is useful to stimulate GITR signaling, thereby inducing or enhancing an immune response in a subject. Accordingly, the antigen binding proteins have utility in a variety of immunotherapy treatments, including treatment of various cancers and infections.