DERIVADOS DE PIRIDINA ACTIVADORES DE GUANILATO CICLASA SOLUBLE

• Main Authors: FRANCOISE JEANNE GELLIBERT, NERINA DODIC, ANNE MARIE JEANNE BOUILLOT, OLIVIER MIRGUET
• Format: Patent
• Language: Spanish
• Published: 17.07.2009
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Se desriben compuestos de formula (I) donde R1 y R2 son independientemente seleccionados de hidrogeno, halo, CF3, C1-4 alquilo y alilo; Donde R3 representa CF3 o C1-4 alquilo y R3a representa CF3 O C1-4 alquilo; R4 representa hidrogeno o metilo; Z está ausente o representa (CH2)2, O o CCH2 A y X son como se definen o sales del mmismo los cuales activan la guanilato ciclasa soluble (sGC), composiciones farmacéuticamente aceptables conteniendo los mismos, su uso en medicina y el proceso para su preparacion. Disclosed are compounds of formula (I) wherein R1 and R2 are independently selected from hydrogen, halo, CF3, C1-4alkyl and allyl; Y represents (II), (III), (IV) or (V) wherein R3 represents CF3 or C1-4alkyl; and R3a represents CF3 or C1-4alkyl.