PROCEDIMIENTO DE PREPARACIÓN DE DERIVADOS DE DIARILCICLOALQUILO

• Main Authors: CHRISTOPH TAPPERTZHOFEN, DI. BERNDT KULITZXCHER, ROLF HOERLEIN, THOMAS STUEDEMANN, CLAUS-JUERGEN MAIER, CHRISTOPHE SALAGNAD, STEPHANE MUTTI, FRANK ZOCHER, BERND JUNKER, WOLFGANG HOLLA, ANDREAS BURGARD, JOCHEN HACHTEL
• Format: Patent
• Language: Spanish
• Published: 31.03.2006
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Un procedimiento de preparación de derivados de diarilcicloalquilo de la fórmula general (I), donde los radicales y sustituyentes tienen los significados especificados en la Memoria Descriptiva. Además, la invención se refiere a nuevos productos intermediarios que se forman en el procedimiento según la invención, y sus procedimientos de preparación, y a un procedimiento de separación de mezclas de isómeros cis/trans de sustancias de partida que se usan en la preparación de compuestos de la fórmula general (I). The invention relates generally to a process for preparing diarylcycloalkyl derivatives of the formula (I). wherein the respective R-group substituents are defined herein. These compounds of formula (I) are activators for peroxisome proliferator-activated receptors (PPAR activators) which are useful in the therapeutic treatment of a number of diseases and disorders of the central nervous system such as multiple sclerosis, Parkinson's Disease, psychiatric disorders and the like. The present invention is a novel process for preparing PPAR activators of the formula (I) which do not have the disadvantages of the processes known in the prior art. In particular, a process is provided with which the PPAR activators of formula (I) can be prepared in a suitable enantiomeric excess, i.e. high enantioselectivity, without the need for subsequent chiral chromatography.