COMPUESTOS Y COMPOSICIONES ANTIPICORNAVIRALES, SUS USOS FARMACÉUTICOS, Y MATERIALES PARA SU SINTESIS

• Main Authors: RU ZHOU, PETER S. DRAGOVICH, THEODORE O. JOHNSON, JR, THOMAS J. PRINS
• Format: Patent
• Language: Spanish
• Published: 29.06.2001
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Se revelan los compuestos de la fórmula: donde las variables de la fórmula son como se define aquí, que ventajosamente inhiben o bloquean la actividad biológica de la proteasa picornaviral 3C. Estos compuestos, así como las composiciones farmacéuticas que contienen estos compuestos, son útiles para el tratamiento de pacientes o huéspedes infectados con uno o más picornaviruses como las proteasas rinovirus 3C. También se describen métodos intermediarios y sintéticos para preparar estos compuestos. Compounds of the formula:where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of the formula:where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described.