Peptides as NS3-serine protease inhibitors of hepatitis C virus

• Main Authors: PINTO PATRICK A, ARASAPPAN ASHOK, MCCORMICK JINPING L, HUANG YUHUA, WANG HAIYAN, GANGULY ASHIT K, HENDRATA SISKA, BOGEN STEPHANE L, ZHU ZHAONING, WU WANLI, TAMURA SUSAN Y, CHAN TIN-YAU, JAO EDWIN, SAKSENA ANIL K, BENNETT FRANK, LEVY ODILE ESTHER, SANTHANAM BAMA, VENKATRAMAN SRIKANTH, GIRIJAVALLABHAN VIYYOOR MOOPIL, PIKE RUSSELL E, KEMP SCOTT JEFFREY, LOVEY RAYMOND G, LIM-WILBY MARGUERITA, CHEN KEVIN X, VACCARO HENRY M, PAREKH TEJAL, LIU YI-TSUNG, NJOROGE F. GEORGE
• Format: Patent
• Language: English
• Published: 03.04.2012
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PEST REPELLANTS OR ATTRACTANTS; PHYSICS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING; TRAPPING

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.