Crystalline forms of carbapenem antibiotics and methods of preparation

A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containin...

Full description

Saved in:
Bibliographic Details
Main Authors BRANDS KAREL M. J, WILLIAMS JOHN M, FISHER ELIZABETH S, CVETOVICH RAYMOND, WARD MICHAEL D, CROCKER LOUIS S, ORELLA CHARLES, JOBSON RONALD, MAHAJAN AMAR J, WENSLOW ROBERT M, SIDLER DANIEL R
Format Patent
LanguageEnglish
Published 23.06.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between -5 and -25° C.
Bibliography:Application Number: US20020999720