Vivo detection of phospholipase activation

The present invention is directed to a phospholipid-based NIR molecular beacon, having a phospholipid moiety; with an NIR fluorophore moiety covalently linked to a phospholipid glycerol backbone and a quencher moiety covalently linked to the phospholipid glycerol backbone. Additionally, provided her...

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Bibliographic Details
Main Authors Zheng, Gang, Mawn, Theresa, Popov, Anatoliy V, Delikatny, E. J
Format Patent
LanguageEnglish
Published 01.05.2018
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Summary:The present invention is directed to a phospholipid-based NIR molecular beacon, having a phospholipid moiety; with an NIR fluorophore moiety covalently linked to a phospholipid glycerol backbone and a quencher moiety covalently linked to the phospholipid glycerol backbone. Additionally, provided herein is methods of analyzing a sample for the presence of a phospholipase and methods of identifying the activity of a phospholipase in vivo utilizing phospholipid-based NIR molecular beacon.
Bibliography:Application Number: US20090920451