Beta hairpin peptides having antiviral properties against Dengue virus

The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these...

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Main Authors Garateix Suárez Rocío, González Blanco Sonia, Chinea Santiago Glay, Falcón Cama Viviana, González López Luis Javier, Martín Dunn Alejandro Miguel, Reyes Acosta Osvaldo, Pupo Gómez Dianne, Márquez Perera Gabriel Jesús, Garay Pérez Hilda Elisa, Vázquez Castillo Mariela, Huerta Galindo Vivian, Sarría Núñez Mónica, Alvarez Pérez Karen, Yero Díaz Alexis, Guirola Cruz Osmany
Format Patent
LanguageEnglish
Published 20.02.2018
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these synthetic peptides, which are useful for the prevention and/or treatment of DENV-caused infections. Likewise, the invention disclosed a method for treating infections caused by this virus.
Bibliography:Application Number: US201515119058