Method for producing 4-borono-L-phenylalanine having 18F atom introduced thereinto, and precursor of 4-borono-L-phenylalanine having 18F atom introduced thereinto

• Main Authors: Takenaka Hiroshi, Taguchi Yusuke, Uehara Kohki, Kirihata Mitsunori, Ueda Sayuri, Ishino Yuko, Yoshikawa Tomohiro, Nakashima Hideki, Ohta Yoichiro
• Format: Patent
• Language: English
• Published: 14.11.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The purpose of the present invention is to provide: a novel method for producing 18 F-labeled 4-boronophenylalanine (BPA) ; and a precursor of 18 F-labeled BPA. 18 F-labeled BPA can be produced by preparing a compound represented by formula (1) and using the compound. In the formula, R1 represents a bromo group, an iodo group, a fluoro group, a diazaborinane derivative, BX3- or BX3-M+ (wherein X represents a halogen atom; and M+ represents a monovalent monoatomic cation, a polyatomic cation or a complex cation).