Selective inhibitors for protein kinases and pharmaceutical composition and use thereof

The present invention provides a compound of formula (I) or the salt thereof: wherein R is at least one selected from the group consisting of unsubstituted C1-4 alkyl, C1-4 alkyl substituted by C6-18 aryl or -OR1, and -C( O)Z. The compound is a type-S protein kinase inhibitor, which binds to an ATP-...

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Main Authors Yang Jinn-Moon, Liu Wan-Chun, Lin Shen Rong, Sung Tzu-Ying, Wang Yun-Ming, Hsu Kai-Cheng, Hsu Kuang-Mei, Lin Hsin-Ping
Format Patent
LanguageEnglish
Published 22.08.2017
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Summary:The present invention provides a compound of formula (I) or the salt thereof: wherein R is at least one selected from the group consisting of unsubstituted C1-4 alkyl, C1-4 alkyl substituted by C6-18 aryl or -OR1, and -C( O)Z. The compound is a type-S protein kinase inhibitor, which binds to an ATP-binding site and a substrate-recognition site of a protein kinase simultaneously. The present invention further provides a pharmaceutical composition, which includes a compound of formula (I) or a salt and a pharmaceutically acceptable carrier thereof. The present invention further provides a use of a compound of formula (I) or a salt thereof, which is for the manufacture of a protein kinase inhibitor as a drug.
Bibliography:Application Number: US201514599349