Pyrazolyl-ureas as kinase inhibitors

There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and membe...

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Main Authors King-Underwood John, Hamza Daniel, Onions Stuart Thomas, Fordyce Euan Alexander Fraser, Fyfe Matthew Colin Thor, Thom Stephen Malcolm, Murray Peter John, Charron Catherine Elisabeth, Cariou Claire Anne Marie, Ito Kazuhiro, Williams Jonathan Gareth, Watson Hayley Tegan Angela
Format Patent
LanguageEnglish
Published 11.07.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
Bibliography:Application Number: US201314422158