1,2,5-Substituted benzimidazoles as flap modulators

The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein ring A, R1, R5 and R6 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula...

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Bibliographic Details
Main Authors Tanis Virginia M, Liu Jing, Chai Wenying, Eccles Wendy, Dvorak Curt A, Deckhut Charlotte, Goldberg Steven D, Tarantino Kyle T, Edwards James P, Krawczuk Paul J, Lebsack Alec D
Format Patent
LanguageEnglish
Published 20.06.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein ring A, R1, R5 and R6 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
Bibliography:Application Number: US201414777481