Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFNα responses

Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition.

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Bibliographic Details
Main Authors Tokarski John S, Wrobleski Stephen T, Moslin Ryan M, Zhang Yanlei, Spergel Steven H, Weinstein David S, Lin Shuqun
Format Patent
LanguageEnglish
Published 29.11.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition.
Bibliography:Application Number: US201314441183