Single chain relaxin polypeptides

The present invention relates to biologically active single chain relaxin polypeptides comprising a relaxin B chain derived from relaxin-3, the polypeptides being truncated by one or more amino acids at the C-terminus of the relaxin-3 B chain. Typically the single chain relaxin polypeptides are anta...

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Main Authors GUNDLACH ANDREW LAWRENCE, WADE JOHN DESMOND, BATHGATE ROSS ALEXANDER DAVID, HAUGAARD-KEDSTROM LINDA MARIA, ROSENGREN KARL JOHAN, HOSSAIN MOHAMMED AKHTER, LAWRENCE ANDREW J
Format Patent
LanguageEnglish
Published 07.06.2016
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Summary:The present invention relates to biologically active single chain relaxin polypeptides comprising a relaxin B chain derived from relaxin-3, the polypeptides being truncated by one or more amino acids at the C-terminus of the relaxin-3 B chain. Typically the single chain relaxin polypeptides are antagonists of the RXFP3 receptor, and in some embodiments are selective antagonists of the RXFP3 receptor.
Bibliography:Application Number: US201113821726