Fused multi-cyclic sulfone compounds as inhibitors of beta-secretase and methods of use thereof

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A5, A6, A8, R1, R2, R3, R7, X, Y, n and o of Formula I, independently, are defined herein. The invention also provides...

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Main Authors EPSTEIN OLEG, WHITE RYAN, STELLWAGEN JOHN, ZHENG XIAO MEI, HUA ZIHAO, SCHENKEL LAURIE, ALLEN JENNIFER R, TAMAYO NURIA A, ROMERO KARINA, OLIVIERI PHILIP R, HUMAN JASON BROOKS, HONG FANG-TSAO, LOPEZ PATRICIA
Format Patent
LanguageEnglish
Published 12.04.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A5, A6, A8, R1, R2, R3, R7, X, Y, n and o of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, compounds of Formula III, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III, and sub-Formulas thereof.
Bibliography:Application Number: US201414166012