Bridged and fused antidiabetic compounds

This invention provides for certain bridged and fused compounds of the formula G-L-A  I or a pharmaceutically acceptable salt, ester of solvate thereof wherein: A is and the other variables are defined herein; the inventive compounds are agonists of the G-protein coupled receptor 40 (GPR40, also kno...

Full description

Saved in:
Bibliographic Details
Main Authors GREENLEE WILLIAM J, JOSIEN HUBERT B, MAYER MICHAEL J, DAVIS JASON L, CLADER JOHN W, WAN SHUANGYI
Format Patent
LanguageEnglish
Published 08.03.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:This invention provides for certain bridged and fused compounds of the formula G-L-A  I or a pharmaceutically acceptable salt, ester of solvate thereof wherein: A is and the other variables are defined herein; the inventive compounds are agonists of the G-protein coupled receptor 40 (GPR40, also known as free fatty acid receptor FFAR). This invention further relates to pharmaceutical compositions containing these compounds, and the use of these compounds to regulate insulin levels in a mammal. The compounds may be used, for example in the prevention and treatment of Type 2 diabetes mellitus and in the prevention and treatment of conditions related to Type 2 diabetes mellitus, such as insulin resistance, obesity and lipid disorders.
Bibliography:Application Number: US201314044316