Modified Cpn10 and PRR signalling

The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to composit...

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Main Authors NAYLOR DEAN JASON, BROWN RICHARD JAMES, HOWARD CHRISTOPHER BRUCE, WARD LINDA ALISSON, VAN HEUMEN WALTER RENE ANTONIUS, STOK JEANETTE ELIZABETH, LAMBERT DANIEL SCOTT, DE BAKKER CHRISTOPHER JOHN, JAMES ANDREW LEIGH, RALSTON KYLIE JANE
Format Patent
LanguageEnglish
Published 12.01.2016
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.
Bibliography:Application Number: US20090934980