Method for enhancing a function of a T cell

Disclosed is a method for enhancing the function of a T cell, which is characterized by inhibiting the expression of programmed death-1 ligand 1 (PD-L1) and/or programmed death-1 ligand 2 (PD-L2) in the T cell. Also disclosed is a function-enhanced T cell which is produced by the function enhancemen...

Full description

Saved in:
Bibliographic Details
Main Authors SHIKU HIROSHI, IKEDA HIROAKI, MINENO JUNICHI, KATO IKUNOSHIN, IWAMURA KOICHI
Format Patent
LanguageEnglish
Published 10.11.2015
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Disclosed is a method for enhancing the function of a T cell, which is characterized by inhibiting the expression of programmed death-1 ligand 1 (PD-L1) and/or programmed death-1 ligand 2 (PD-L2) in the T cell. Also disclosed is a function-enhanced T cell which is produced by the function enhancement method. Further disclosed is a therapeutic agent comprising the function-enhanced T cell. The T cell can enhance an immune response to cancer, and is useful in an immunotherapy effective for cancer and the treatment or prevention of infectious diseases and autoimmune diseases.
Bibliography:Application Number: US201013254602