Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

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Bibliographic Details
Main Authors TAO ZHI-FU, MANTEI ROBERT A, WANG GARY T, PARK CHANG H, HASVOLD LISA, WANG LE, SONG XIAOHONG, PARK CHEOL-MIN, ELMORE STEVEN W, BRUNCKO MILAN, SULLIVAN GERARD M, SOUERS ANDREW J, WANG XILU, MCCLELLAN WILLIAM J, PETROS ANDREW M, WENDT MICHAEL D, DOHERTY GEORGE A, DING HONG, KUNZER AARON R, HEXAMER LAURA A
Format Patent
LanguageEnglish
Published 08.09.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
Bibliography:Application Number: US201314058159