Method for native ligation of polypeptides

The invention mainly relates to a method for manufacturing a polypeptide of formula: X1-X″-X2  (III) X1 and X2 each representing a peptide fragment, and X″ representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypept...

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Main Authors OLLIVIER NATHALIE, DHEUR JULIEN, MHIDIA REDA, MELNYK OLEG
Format Patent
LanguageEnglish
Published 12.05.2015
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Abstract The invention mainly relates to a method for manufacturing a polypeptide of formula: X1-X″-X2  (III) X1 and X2 each representing a peptide fragment, and X″ representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula: X1-N(CH2CH2SH)2  (I) and a polypeptide of formula: H-X″-X2.  (II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.
AbstractList The invention mainly relates to a method for manufacturing a polypeptide of formula: X1-X″-X2  (III) X1 and X2 each representing a peptide fragment, and X″ representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula: X1-N(CH2CH2SH)2  (I) and a polypeptide of formula: H-X″-X2.  (II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.
Author MHIDIA REDA
DHEUR JULIEN
OLLIVIER NATHALIE
MELNYK OLEG
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Snippet The invention mainly relates to a method for manufacturing a polypeptide of formula: X1-X″-X2  (III) X1 and X2 each representing a peptide fragment, and X″...
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METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Title Method for native ligation of polypeptides
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