Method for native ligation of polypeptides

The invention mainly relates to a method for manufacturing a polypeptide of formula: X1-X″-X2  (III) X1 and X2 each representing a peptide fragment, and X″ representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypept...

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Bibliographic Details
Main Authors OLLIVIER NATHALIE, DHEUR JULIEN, MHIDIA REDA, MELNYK OLEG
Format Patent
LanguageEnglish
Published 12.05.2015
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The invention mainly relates to a method for manufacturing a polypeptide of formula: X1-X″-X2  (III) X1 and X2 each representing a peptide fragment, and X″ representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula: X1-N(CH2CH2SH)2  (I) and a polypeptide of formula: H-X″-X2.  (II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.
Bibliography:Application Number: US201013504054