Posaconazole intravenous solution formulations stabilized by substituted -cyclodextrin

The present invention relates to aqueous solutions useful as pharmaceutical compositions of posaconazole for intravenous administration. These compositions include a solubilizing agent, such as a modified -cyclodextrin in an acidified solution, which can also include a chelating agent such as disodi...

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Bibliographic Details
Main Authors MONTEITH DAVID, PIPKIN JAMES D, HEIMBECHER SUSAN K
Format Patent
LanguageEnglish
Published 05.05.2015
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to aqueous solutions useful as pharmaceutical compositions of posaconazole for intravenous administration. These compositions include a solubilizing agent, such as a modified -cyclodextrin in an acidified solution, which can also include a chelating agent such as disodium edetate (EDTA). In clinical trials, a 200 mg posaconazole dose of the selected composition was found to achieve acceptable pharmacokinetic properties.
Bibliography:Application Number: US201113704145