Salts of prodrugs of piperazine and substituted piperidine antiviral agents

• Main Authors: MEANWELL NICHOLAS A, WANG TAO, THORAVAL DOMINIQUE, PACK SHAWN K, CONNOLLY TIMOTHY P, KADOW JOHN F, YEUNG KAP-SUN, LEAHY DAVID KENNETH, SOUNDARARAJAN NACHIMUTHU, CHEN CHUNG-PIN H, SIRARD PIERRE, UEDA YASUTSUGU, LEVESQUE KATHIA, ZHANG ZHONGXING
• Format: Patent
• Language: English
• Published: 28.10.2014
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.