Adenoviral vector-based malaria vaccines

• Main Authors: KING C. RICHTER, KOVESDI IMRE, MCVEY DUNCAN L, CARUCCI DANIEL JOHN, ETTYREDDY DAMODAR R, DOOLAN DENISE LOUISE, BRUDER JOSEPH T
• Format: Patent
• Language: English
• Published: 01.07.2014
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention provides adenoviral vectors comprising an adenoviral genome comprising heterologous antigen-encoding nucleic acid sequences, such as Plasmodium nucleic acid sequences, operably linked to promoters. The invention further provides a method of inducing an immune response against malaria i...