Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media

• Main Authors: LEACH ANDREW MICHAEL, MILLER PETER, TELFEYAN ERIC, WHITT DAVID BRANDON
• Format: Patent
• Language: English
• Published: 01.07.2014
• Subjects: BLASTING; COMBINED HEATING AND REFRIGERATION SYSTEMS; DIAGNOSIS; HEAT PUMP SYSTEMS; HEATING; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; LIGHTING; LIQUEFACTION SOLIDIFICATION OF GASES; MANUFACTURE OR STORAGE OF ICE; MEASURING; MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES; MECHANICAL ENGINEERING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; REFRIGERATION MACHINES, PLANTS OR SYSTEMS; REFRIGERATION OR COOLING; SURGERY; TESTING; WEAPONS

Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution, transporting the aqueous solution through a fluid path system out of the polarizer, filtering the aqueous solution through a partical size exclusion filter to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial for containing a hyperpolarized imaging agent therein, a dissolution fluid path, a delivery fluid path, a particle size exclusion filter, and a receiver connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.