FGF21 conjugates and anti-diabetic uses thereof

• Main Authors: VIOLAND BERNARD NORMAN, LEVIN NANCY JANE, DAS TAPAN KANTI, PARSONS ERIN KRISTEN, ISHINO TETSUYA, HODGE TAMARA SHAFER, PALANKI MOORTHY SITHARAMAIAH SURIYANARAYANA
• Format: Patent
• Language: English
• Published: 13.05.2014
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides a FGF21 molecule covalently attached to the combining site of an antibody via a linker, wherein the linker is covalently attached to the side chain of a linking residue within FGF21. Various uses of the compounds are provided, including methods to prevent or treat diab...