Anti-ferroportin 1 monoclonal antibodies and uses thereof

Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte coun...

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Main Authors TANG YING, LUAN PENG, LEUNG DONMIENNE DOEN MUN, MANETTA JOSEPH VINCENT, WITCHER DERRICK RYAN
Format Patent
LanguageEnglish
Published 25.03.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
Bibliography:Application Number: US201213465462