Amorphous silibinin for the treatment of viral hepatitis

The invention relates to a method for the preparation of amorphous silibinin (or its synonyms: silybin or silibin) derived from a milk thistle fruit extract having an increased release rate and improved absorbability or bioavailability, and to the use of amorphous silibinin for the treatment or prev...

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Bibliographic Details
Main Authors XIOL AGUIRRE JAIME, RULL PROUS SANTIAGO, NAGELL ASTRID, POHL RALF-TORSTEN, ROVATI LUCIO CLAUDIO, MENGS ULRICH
Format Patent
LanguageEnglish
Published 24.12.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a method for the preparation of amorphous silibinin (or its synonyms: silybin or silibin) derived from a milk thistle fruit extract having an increased release rate and improved absorbability or bioavailability, and to the use of amorphous silibinin for the treatment or prevention of liver diseases, preferably for the treatment of viral hepatitis, e.g. hepatitis B or C, in particular in a patient who will undergo or has undergone liver transplantation. Preferably, the amorphous silibinin is adapted for oral administration.
Bibliography:Application Number: US201013320176