Diaminoalkane aspartic protease inhibitors

• Main Authors: DILLARD LAWRENCE W, WERY JEAN-PIERRE, SIMPSON ROBERT D, ISHCHENKO ALEXEY V, CLAREMON DAVID A, MCGEEHAN GERARD, YUAN JING, CACATIAN SALVACION, XU ZHENRONG, SINGH SURESH B, ZHAO WEI, TICE COLIN M, FLAHERTY PATRICK T, BALDWIN JOHN J
• Format: Patent
• Language: English
• Published: 04.06.2013
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Diaminoalkanes of below Formula I have now been found which are orally active and bind to aspartic proteases to inhibit their activity: They are useful in the treatment or amelioration of diseases associated with elevated levels of aspartic protease activity. The invention also relates to a method f...