Diaminoalkane aspartic protease inhibitors

Diaminoalkanes of below Formula I have now been found which are orally active and bind to aspartic proteases to inhibit their activity: They are useful in the treatment or amelioration of diseases associated with elevated levels of aspartic protease activity. The invention also relates to a method f...

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Main Authors DILLARD LAWRENCE W, WERY JEAN-PIERRE, SIMPSON ROBERT D, ISHCHENKO ALEXEY V, CLAREMON DAVID A, MCGEEHAN GERARD, YUAN JING, CACATIAN SALVACION, XU ZHENRONG, SINGH SURESH B, ZHAO WEI, TICE COLIN M, FLAHERTY PATRICK T, BALDWIN JOHN J
Format Patent
LanguageEnglish
Published 04.06.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Diaminoalkanes of below Formula I have now been found which are orally active and bind to aspartic proteases to inhibit their activity: They are useful in the treatment or amelioration of diseases associated with elevated levels of aspartic protease activity. The invention also relates to a method for the use of the compounds of Formula I in ameliorating or treating aspartic protease related disorders in a subject in need thereof comprising administering to said subject an effective amount of a compound of Formula I.
Bibliography:Application Number: US20100802142