Altered peptide ligand derived from HSP60 and pharmaceutical compositions

Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of...

Full description

Saved in:
Bibliographic Details
Main Authors HORTA MARIA DEL CARMEN DOMINGUEZ, DIAZ CARELIA COSME, MERINO GARCIA NELSON J, PALOMARES GABRIEL RAMON PADRON, BONACHEA ARIEL VAZQUEZ, ALBA JOSE SUAREZ, HERNANDEZ GARCIA ARIADNA, BETANCOURT ARIANA BARBERA, PEREZ NORAILYS LORENZO, LOPEZ MARIN NELIA, CORDOVA VIVIAN MORERA
Format Patent
LanguageEnglish
Published 26.02.2013
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
Bibliography:Application Number: US20050663603