Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof

Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful int...

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Main Authors LUDWIKOW MARIA, YAO FENMEI, BHAT SEEMA, SCHEUERMAN RANDALL A, MANTHATI SURESH K, GALLOP MARK A, DAI XUEDONG, RAILLARD STEPHEN P, PENG GE, PHAN THU
Format Patent
LanguageEnglish
Published 19.02.2013
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
Bibliography:Application Number: US201113208176