Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful int...
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Main Authors | , , , , , , , , , |
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Format | Patent |
Language | English |
Published |
19.02.2013
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Subjects | |
Online Access | Get full text |
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Summary: | Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described. |
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Bibliography: | Application Number: US201113208176 |