Systems and methods for delivery of a therapeutic agent

Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum...

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Bibliographic Details
Main Authors DEEM MARK E, GIFFORD HANSON
Format Patent
LanguageEnglish
Published 25.12.2012
Subjects
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
BANDAGES, DRESSINGS OR ABSORBENT PADS
BEER
BIOCHEMISTRY
CHEMISTRY
DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS
ENZYMOLOGY
FILTERS IMPLANTABLE INTO BLOOD VESSELS
FIRST-AID KITS
FOMENTATION
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES
PHYSICS
PROSTHESES
SPIRITS
TESTING
TREATMENT OR PROTECTION OF EYES OR EARS
VINEGAR
WINE
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Summary:Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.
Bibliography:Application Number: US201113253595