Inhibitors of janus kinases and/or 3-phosphoinositide-dependent protein kinase-1

The instant invention provides for compounds that inhibit JAK2 tyrosine kinase and/or PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting JAK2 tyrosine kinase activity and/or PDK1 kinase inhibitory activity by administering the compound t...

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Bibliographic Details
Main Authors YOUNG JONATHAN, GUERIN DAVID J, JUNG JOON O, DINSMORE CHRISTOPHER, NORTHRUP ALAN, ALTMAN MICHAEL, KOZINA EKATERINA, KATTAR SOLOMON, SIU TONY, MACCOSS RACHEL N, KEENAN KEVIN A
Format Patent
LanguageEnglish
Published 11.12.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The instant invention provides for compounds that inhibit JAK2 tyrosine kinase and/or PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting JAK2 tyrosine kinase activity and/or PDK1 kinase inhibitory activity by administering the compound to a patient in need of treatment or prevention of myeloproliferative disorders or cancer.
Bibliography:Application Number: US20080530648