Anti A beta antibody formulation

The present invention provides formulations for maintaining the stability of A binding polypeptides, for example, A antibodies. Exemplary formulations include a tonicity agent such as mannitol and a buffering agent or amino acid such as histidine. Other exemplary formulations include an antioxidant...

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Bibliographic Details
Main Authors LUISI DONNA, KANTOR ANGELA, WARNE NICHOLAS W
Format Patent
LanguageEnglish
Published 27.11.2012
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides formulations for maintaining the stability of A binding polypeptides, for example, A antibodies. Exemplary formulations include a tonicity agent such as mannitol and a buffering agent or amino acid such as histidine. Other exemplary formulations include an antioxidant in a sufficient amount as to inhibit by-product formation, for example, the formation of high molecular weight polypeptide aggregates, low molecular weight polypeptide degradation fragments, and mixtures thereof. The formulations of the invention optionally comprise a tonicity agent, such as mannitol, and a buffering agent or amino acid such as histidine. The formulations are suitable for several different routes of administration.
Bibliography:Application Number: US20090637508