Endotoxin adsorbent for the prevention and treatment of autoimmune diseases

It is believed that the abnormal absorption of endotoxin present in the gastrointestinal tract relates to the pathogenesis of autoimmune diseases such as rheumatoid arthritis. In an animal model for rheumatoid arthritis, it is observed that arthritis is improved by removing endotoxin. The present in...

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Bibliographic Details
Main Authors SHIONOYA HIROSHI, TERATO KUNIAKI, IWASHITA SADAICHI
Format Patent
LanguageEnglish
Published 16.10.2012
Subjects
AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
AGRICULTURE
ANIMAL HUSBANDRY
BUILDING
FINISHING WORK ON BUILDINGS, e.g. STAIRS, FLOORS
FISHING
FIXED CONSTRUCTIONS
FORESTRY
HUMAN NECESSITIES
HUNTING
MANUFACTURE OF DAIRY PRODUCTS
PERFORMING OPERATIONS
SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDEDFOR
SHAPING OR JOINING OF PLASTICS
TRANSPORTING
TRAPPING
WORKING OF PLASTICS
WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
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Summary:It is believed that the abnormal absorption of endotoxin present in the gastrointestinal tract relates to the pathogenesis of autoimmune diseases such as rheumatoid arthritis. In an animal model for rheumatoid arthritis, it is observed that arthritis is improved by removing endotoxin. The present invention provides an endotoxin-adsorbent, which is capable of removing endotoxin in the gastrointestinal tract and can be administered to humans safely. By using a non-digestible and non-absorbable, and therefore, safe endotoxin-adsorbent, which has a high endotoxin-binding capacity for removing large amounts of endotoxin present in the gastrointestinal tract, it is possible to prevent and treat autoimmune diseases such as rheumatoid arthritis.
Bibliography:Application Number: US20100804945