Preparation of porous particles with multiple markers

• Main Authors: NAIR MRIDULA, JONES TAMARA K, KAPP DANIEL L
• Format: Patent
• Language: English
• Published: 07.02.2012
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMISTRY; COMPOSITIONS BASED THEREON; GENERAL PROCESSES OF COMPOUNDING; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; WORKING-UP

Porous particles are prepared using a first water-in-oil emulsion comprising a first marker material in a first aqueous phase that is dispersed in a first oil phase containing a polymer and a first organic solvent, and a second water-in-oil emulsion comprising a second marker material in a second aqueous phase that is dispersed in a second oil phase. The first and second marker materials are detectably different. The two water-in-oil emulsions can be used to form a third water-in-oil emulsion containing distinct droplets of the first and second aqueous phases. This third water-in-oil emulsion is dispersed in a third aqueous phase containing a surface stabilizing agent to form a water-in-oil-in-water emulsion containing droplets of the third water-in-oil emulsion. The organic solvents are removed from the water-in-oil-in-water emulsion to form porous particles comprising first and second discrete pores that are isolated from each other. The first marker material is present within the first discrete pores, and the second marker material is present within the second discrete pores.