Spiro-oxindole compounds and their uses as therapeutic agents

This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which...

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Main Authors SUN SHAOYI, SUN JIANYU, FRASER ROBERT, CHAKKA NAGASREE, CHOWDHURY SULTAN, KAMBOJ RAJENDER, FU JIANMIN, BAGHERZADEH MEHRAN SEID, LIU SHIFENG, RAINA VANDNA, SVIRIDOV SERGUEI, CHAFEEV MIKHAIL, HOU DUANJIE, HSIEH TOM
Format Patent
LanguageEnglish
Published 31.01.2012
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
Bibliography:Application Number: US20090650196