JAK-2 modulators and methods of use

This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibit...

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Main Authors TAKEUCHI CRAIG STACY, JOHNSON HENRY WILLIAM BEECROFT, GALAN ADAM ANTONI, KEARNEY PATRICK, MANN GRACE, FORSYTH TIMOTHY, ZHOU PEIWEN, LEAHY JAMES W, CHEN JEFF, DU HONGWANG, HUYNH TAI PHAT, RIDGWAY BRIAN HUGH, LEE MATTHEW SANGYUP
Format Patent
LanguageEnglish
Published 03.01.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.
AbstractList This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.
Author CHEN JEFF
DU HONGWANG
TAKEUCHI CRAIG STACY
MANN GRACE
FORSYTH TIMOTHY
KEARNEY PATRICK
LEAHY JAMES W
ZHOU PEIWEN
HUYNH TAI PHAT
RIDGWAY BRIAN HUGH
LEE MATTHEW SANGYUP
GALAN ADAM ANTONI
JOHNSON HENRY WILLIAM BEECROFT
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– fullname: ZHOU PEIWEN
– fullname: LEAHY JAMES W
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– fullname: HUYNH TAI PHAT
– fullname: RIDGWAY BRIAN HUGH
– fullname: LEE MATTHEW SANGYUP
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HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title JAK-2 modulators and methods of use
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