Synthetic peptides useful in biological essays for detecting infections caused by group O HIV-1 viruses

• Main Authors: GADELLE STEPHANE JEAN XAVIER, RIEUNIER FRANCOIS YVES, CHENEBAUX DENIS MARIE BERNARD, DELAGNEAU JEAN-FRANCOIS HUBERT
• Format: Patent
• Language: English
• Published: 23.11.2010
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I): -Z-TrpGlyCys-Θ-CysTyrThrSer-   (I) wherein is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CH3CO-) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence - 1-Ser- 2-, - 1-Gln- 2-, or - 1-Asn- 2-, wherein - 1 represents a peptide sequence of 0 to 9 amino acids and - 2 represents a peptide sequence of 0 to 5 amino acids, Θis -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile-(SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), , attached to the -CO- group of serine, is a hydroxyl (-OH) radical, an amino (-NH2) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val- -Ψ wherein represents a sequence of formula -(AA1)-Trp Asn-(AA2)-(AA3) wherein (AA1) represents an amino acid different from lysine, (AA2) represents an amino acid, and (AA3) is serine or a threonine residue, and Ψ, attached to the -CO- residue of the free AA3 amino acid, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-Ψ wherein Ψ, attached to the -CO- residue of valine, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms.