Thiophene and thiazole substituted trifluoroethanone derivatives as histone deacetylase (HDAC) inhibitors

The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. They are also useful...

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Bibliographic Details
Main Authors MURAGLIA ESTER, ONTORIA ONTORIA JESUS MARIA, JONES PHILIP, SCARPELLI RITA, FERRIGNO FEDERICA, SCHULTZ-FADEMRECHT CARSTEN
Format Patent
LanguageEnglish
Published 21.09.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. They are also useful for treating neurodegenerative diseases, mental retardation, 10 schizophrenia, inflammatory diseases, restenosis, immune disorders, diabetes, cardiovascular disorders and asthma.
Bibliography:Application Number: US20070223943