Antisense oligonucleotides with increased RNase sensitivity
Combinatorial libraries comprise first oligonucleotide analogs and second oligonucleotide analogs which are coupled together to form antisense molecules capable of binding target polynucleotides and activating an RNase, and ribozymes capable of cleaving polynucleotides.
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Main Authors | , , |
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Format | Patent |
Language | English |
Published |
07.09.2010
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Subjects | |
Online Access | Get full text |
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Summary: | Combinatorial libraries comprise first oligonucleotide analogs and second oligonucleotide analogs which are coupled together to form antisense molecules capable of binding target polynucleotides and activating an RNase, and ribozymes capable of cleaving polynucleotides. |
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Bibliography: | Application Number: US20020142566 |