6-carboaryl-oxy-pyrazin-2-yl-carboaryl-amines and compositions comprising said compounds

The present invention pertains to certain 6-carboaryloxy-pyrazin-2-yl-carboaryl-amines of the following formula, and pharmaceutically acceptable salts thereof, which, inter alia, inhibit RAF (e.g., B-RAF) activity, inhibit cell proliferation, treat cancer, etc., wherein Q is independently -N ; RP3 i...

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Bibliographic Details
Main Authors VELA ESTEBAN ROMAN, MARAIS RICHARD MALCOLM, NICULESCU-DUVAZ ION, SPRINGER CAROLINE JOY, TAYLOR RICHARD DAVID, GILL ADRIAN LIAM
Format Patent
LanguageEnglish
Published 15.06.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention pertains to certain 6-carboaryloxy-pyrazin-2-yl-carboaryl-amines of the following formula, and pharmaceutically acceptable salts thereof, which, inter alia, inhibit RAF (e.g., B-RAF) activity, inhibit cell proliferation, treat cancer, etc., wherein Q is independently -N ; RP3 is independently a group of the formula -J1-L1-Z; -J1L1-Z is independently -NH-Z; Z is independently C6-14carboaryl and is independently unsubstituted or substituted; RP2 is independently -H; RP5 is independently a group of the formula -W-Y; W is independently -O-; Y is independently C6-14 carboaryl and is independently unsubstituted or substituted; and RP6 is independently -H. The present invention also pertains to pharmaceutical compositions comprising such compounds.
Bibliography:Application Number: US20050722612