Crystalline polymorphs of methanesulfonic acid addition salts of Imatinib

This invention relates to the methanesulfonic acid addition salts of Imatinib and to the synthesis thereof. In particular, this invention relates to the synthesis of crystalline α-form of Imatinib methanesulfonate. Furthermore, the invention is directed to a novel acid addition salt of 4-(4-methylpi...

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Main Authors KORCZAK KATARZYNA, KACZMAREK LUKASZ, ZAGRODZKI BOGDAN, SAMSON-LAZINSKA DOROTA, FRACZEK URSZULA, LAWECKA MARTA, CMOCH PIOTR, MODZELEWSKI RYSZARD, MARUSZAK WIOLETA, GLICE MAGDALENA, SZELEJEWSKI WIESLAW, SZCZEPEK WOJCIECH
Format Patent
LanguageEnglish
Published 08.06.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to the methanesulfonic acid addition salts of Imatinib and to the synthesis thereof. In particular, this invention relates to the synthesis of crystalline α-form of Imatinib methanesulfonate. Furthermore, the invention is directed to a novel acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-[(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]benzamide with two molecules of methanesulfonic acid and to the polymorphic forms thereof, as well as to their pharmaceutical compositions.
Bibliography:Application Number: US20050599461