Pyrazole compounds as transforming growth factor (TGF) inhibitors

Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-<i...

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Bibliographic Details
Main Authors BLUMBERG LAURA C, MUNCHHOF MICHAEL J
Format Patent
LanguageEnglish
Published 29.12.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-<img id="CUSTOM-CHARACTER-00001" he="2.79mm" wi="1.78mm" file="US07638537-20091229-P00001.TIF" alt="custom character" img-content="character" img-format="tif"/> signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
Bibliography:Application Number: US20060557638