Antibodies against human interleukin-13 and pharmaceutical compositions thereof

This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preve...

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Main Authors GOLDMAN SAMUEL J, VELDMAN GEERTRUIDA M, DONALDSON DEBRA D, MARQUETTE KIMBERLY ANN, FEYFANT ERIC, KASAIAN MARION T, LIN LAURA LONG, TCHISTIAKOVA LIOUDMILA, TAN XIANG-YANG, WOOD NANCY L, WIDOM ANGELA M, SHANE TANIA, PARRIS KEVIN D, PUI TAM AMY SZE, FITZ LORI J, SALDANHA JOSE W
Format Patent
LanguageEnglish
Published 10.11.2009
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
Bibliography:Application Number: US20050149309