5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin and its preparation and use for the treatment of cancer

A 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2'-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2'-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutic...

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Main Authors REKA AJAYA KUMAR, ALIKUNJU SHANAVAS, MULLANGI RAMESH, SIRISILLA RAJU, AKELLA VENKATESWARLU, DUVVURI SUBRAHMANYAM, RAJAGOPAL SRIRAM
Format Patent
LanguageEnglish
Published 13.10.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2'-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2'-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.
Bibliography:Application Number: US20070753432