Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith

Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condit...

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Main Authors HUGHES KEVIN, PALANKI MOORTHY S. S, HILGRAF ROBERT, PLANTEVIN-KRENITSKY VERONIQUE, SAHASRABUDHE KIRAN, NADOLNY LISA, SATOH YOSHITAKA, SUDBECK ELISE, WRIGHT JONATHAN, MCCARRICK MEG, CLAREEN STEVEN S, AYALA LETICIA, DELGADO MEDEROS MARIA MERCEDES, SLOSS MARIANNE K, ALBERS RONALD J, KOIS ADAM
Format Patent
LanguageEnglish
Published 21.04.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
Bibliography:Application Number: US20060411413