High affinity quinoline-based kinase ligands

Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provide...

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Bibliographic Details
Main Authors FISCHMANN THIERRY O, WINDSOR WILLIAM T, MADISON VINCENT S, ZHANG RUMIN, CURRAN PATRICK J, MCNEMAR CHARLES W, DENG YONGQI, LEES EMMA M, ZHAO LIANYUN, HRUZA ALAN W, DUCA JOSE S, PARRY DAVID A, SHIPPS, JR. GERALD W, MAYHOOD TODD W, SIDDIQUI M. ARSHAD, POPOVICI-MULLER JANETA
Format Patent
LanguageEnglish
Published 31.03.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
Bibliography:Application Number: US20060504869