Substituted 1,4,-di-piperidin-4-yl-piperazine derivatives and their use as neurokinin antagonists

The invention concerns substituted 1,4-di-piperidin-4-yl-piperazine derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment of emesis, anxiety, depressio...

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Main Authors VAN ROOSBROECK YVES EMIEL MARIA, SOMMEN FRANCOIS MARIA, LEENAERTS JOSEPH ELISABETH, DIELS GASTON STANISLAS MARCELLA, DE BOECK BENOIT CHRISTIAN ALBERT GHISLAIN, JANSSENS FRANS EDUARD
Format Patent
LanguageEnglish
Published 12.08.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention concerns substituted 1,4-di-piperidin-4-yl-piperazine derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment of emesis, anxiety, depression, pain, pancreatitis and IBS.
Bibliography:Application Number: US20050527821